In a June 22, 2020, Orthomolecular Medicine News Service press release, 1 Damien Downing, president of the British Society for Ecological Medicine, outlines how we could resolve the COVID-1 9 pandemic in 30 days for about$ 2 per person, simply by taking affirmative action to raise vitamin D levels. The downside or risk of doing this is basically nil, while the potential gain could be avoiding another COVID-1 9 spike altogether.
“If we could arrange to give everyone vitamin D, and it failed to protect them, so what? The risk from not acting is much greater than health risks from behaving, ” Downing says, adding: “If you caught the COVID1 9 virus right now, having a good vitamin D status( from already having taken a supplement) would
Reduce your risk of the disease becoming severe by 90%
Reduce your risk of dying by 96%
This is not ‘proven’ or ‘evidence-based’ until we have done controlled experiments likening it to placebo … But the data, already strong, has been pouring in since the start of the pandemic.”
Although the required prospective randomized controlled trials use vitamin D have not yet been completed, they are indeed underway and results from many will be in before year’s end. You can visit the clinical experiments registry to review the current state of these tests. 2,3 As of June 2020, there is indeed over 20 studies in progress on the use of vitamin D in COVID-1 9.
Vitamin D and COVID-1 9
Downing goes on to quote the studies and supporting data. Among them is a study4 from the Philippines, which found that for each standard irregularity increase in serum vitamin D, the odds of experiencing only mild illnes rather than severe illness was 7.94 times larger, and the odds of having a mild clinical outcome rather than a critical outcome was 19.61 times greater. According to the author 😛 TAGEND
“The outcomes suggest that an increase in serum 25( OH) D tier in the body could either improve clinical outcomes or mitigate worst( severe to critical) outcomes, while a decrease in serum 25( OH) D degree in their own bodies could worsen clinical outcomes of COVID-2 019 patients.”
Another study5 from Indonesia, which looked at data from 780 COVID-1 9 patients, obtained those with a vitamin D grade between 20 ng/ mL( 50 nmol/ L) and 30 ng/ mL( 75 nmol/ L) had a sevenfold higher hazard of death than those with a grade above 30 ng/ mL. Having a grade below 20 ng/ mL was associated with a 12 times higher risk of death. As noted by Downing: 6
“With a insufficient vitamin D status (< 50 nmol/ L) the mortality rate from COVID-1 9 was 98.8% against 4.1% with adequate vitamin D (> 75 nmol/ L ). The Hazard Ratio is 24.1 … A Hazard Ratio of 4 means that in one condition, for instance vitamin D insufficiency, “youre gonna” 4 times more likely to suffer the ‘hazard’ than in another condition, say vitamin D adequacy.”
A third paper, 7 which provides data from 20 European countries, likewise found that “the probability of developing COVID-1 9, and of dying from it, is negatively related with entail population vitamin D status, with both likelihoods reaching zero above about 75 nmol/ L, “( 30 ng/ mL) Downing tones. 8P TAGEND
A vitamin D3 blood level of at least 75 nmol/ L( 30 ng/ ml) is needed for protection against COVID-1 9.
In their preprint submission of this paper, 9 the authors concluded, “We believe that we can advise vitamin D supplementation to protect against SARS-CoV2 infection.” Downing developed the following graph1 0 to illustrate the data provided in the working paper.
Vitamin D Level Above 30 ng/ mL Protects You Against COVID-1 9
Downing also addresses the issue of dosage and safety, highlighting how admonishes about “excessive vitamin D intakes” being dangerous are very misleading and unwarranted, as toxicity has not been demonstrated until you reached blood tiers above 200 ng/ mL( 500 nmol/ L ).
The recommended blood tier for optimal health is currently between 60 ng/ mL( 150 nmol/ L) and 80 ng/ mL( 200 nmol/ L ). In other words, there’s a significant margin of safety, even though they are you manage to outperformed the optimal range.
“The three papers1 1,12, 13 mentioned above show that a vitamin D3 blood level of at least 75 nmol/ L( 30 ng/ ml) is needed for protection against COVID-1 9, ” Downing writes. 14
“Government recommendations for vitamin D intake — 400 IU/ day for the UK and 600 IU/ period for the USA ( 800 IU for> 70 times) and the EU — are based primarily on bone health. This is woefully inadequate in the pandemic context.
An adult will need to take 4,000 IU/ period of vitamin D3 for three months to reliably reach a 75 nmol/ L tier. 15 Persons of coloring may need twice as much. 16 These dosages can reduce the risk of infection, but are not for treatment of an acute viral infection.
And since vitamin D is fat-soluble and its level in the body rises gradually, for those with a deficiency, taking an initial dose of 5-fold the normal dose( 20,000 IU/ day) for two weeks can help to raise the tier up to an adequate level to lower infection risk.”
Become Metabolically Flexible and Insulin Sensitive
As discussed in my interview with Dave Asprey, featured in “How Ketones May Be Useful Against COVID-1 9, ” being metabolically flexible is another important lifestyle component. The reason for this is because insulin resistance attains you more susceptible to cytokine cyclone, a primary cause of death among COVID-1 9 patients.
The single most important step you can take to attain metabolic flexibility is to cut down the hours during which you devoured. More than 90% of people eat for more than 12 hours a day, and more than half eat for more than 16 hours per day. The key reduction of your eating window to six to eight hours, making sure the last food you ate is at least three hours before you go to bed.
When you curtail your eating window you will decrease insulin opposition, become more metabolically flexible and able to seamlessly switch back and forth between burning fat or carbs as your primary fuel. I wrote an entire journal on how to become metabolically flexible, “Fat for Fuel, ” but a simple summary is as follows 😛 TAGEND
Time-restrict your eating window to six to eight hours
Eliminate all industrially processed vegetable oils
Limit carbs to 50 grams a day until metabolically flexible and then increase to 150 grams of healthy carbs twice a week
This strategy is absolutely vital in light of the prevalence of insulin opposition. Over 90% of the U.S. is vitamin D deficient; 90% of the population is also insulin resistant. Research1 7 published in Metabolic Syndrome and Related Disorders in February 2019 reached the conclusion that 87.8% of the U.S. adults sampled were metabolically inflexible, which means they cannot efficiently burn fat for fuel.
Ketones May Also Be Useful Against COVID-1 9
When “youre gonna” insulin sensitive, metabolically flexible and feeing a cyclical low-carb diet, you will be able to generate healthy ketone tiers. Remember that constant ketosis and low-carb is an unhealthy strategy. It is fine to go low-carb for a few months, but for optimal health you need to cycle health carbs back in once or twice a week, ideally when you are doing your hardest practise or resistance training of the week.
When you burn carbohydrate for gasoline, there is a requirement to break glucose down to two molecules of 3 carbon pyruvate. Pyruvate is then be followed by your mitochondria after it is converted to acetyl CoA. Insulin resistance, in turn, can impair the enzyme that converts a dislocation product of glucose into pyruvate so it can be shuttled and burned as vitality in your mitochondria.
The problem with COVID-19 is that the cytokine storm inhibits the enzyme converting pyruvate to acetyl CoA
NADPH is the battery of your cell
NADPH also turns off NLRP3 inflammasome that produces cytokines like TNF alpha
All of that said
To address insulin resistance and metabolic inflexibility in the long termMolecular Hydrogen
Molecular hydrogen( H2 gas) has powerful antioxidant and anti-inflammatory impacts, 18 establishing it is helpful for COVID-1 9 by reducing inflammatory cytokines, as has been described in this video by Tyler W. LeBaron, founder of the science-based nonprofit Molecular Hydrogen Institute.
In his video, LeBaron examines the pathophysiology of COVID-1 9 and explains why H2 is being clinically investigated by discussing the proposed mechanisms of how molecular hydrogen might mitigate this particular disease.
Molecular hydrogen or H2 has the ability to activate the Nrf2/ keap1 pathway, thereby replenishing your endogenous antioxidants. In so doing, H2 assists govern and maintain homeostasis in the whole system, avoiding the infection from get out of power and making cell demise.
Hydrogen can also downregulate NOX and NOS enzymes, thus lowering superoxide and nitric oxide make respectively. “Its good”, as when these two molecules are increased too much they instantly combine to create the pernicious peroxynitrite molecule. H2 also substantiates your mitochondrial role. Importantly, H2 selectively reduces peroxynitrites and hydroxyl radicals.
H2 likewise steps in to prevent a cytokine hurricane from arising. For a written summary of LeBaron’s video lecturing, interpret “How Molecular Hydrogen Can Help Against COVID-1 9.” H2 will likewise help improve NADPH, and jobs synergistically with time-restricted devouring and cyclical ketosis.
Quercetin Plus Zinc May Lower COVID-1 9 Risk Further
In addition to vitamin D optimization, quercetin — which acts similarly to the narcotic hydroxychloroquine — and zinc1 9 may further lower the health risks of COVID-1 9. Compelling proof suggests the reason hydroxychloroquine seems so useful in the treatment of COVID-1 9 is a zinc ionophore, entailing it improves zinc uptake into the cell.
Quercetin has the same effect. In reality, one study2 0 has suggested the biological actions — which include antiviral influences — of quercetin may in fact be related to its ability to increase cellular zinc uptake.
Zinc is vital for healthy immune function2 1 and a combination of zinc with a zinc ionophore( zinc transportation molecule) was in 2010 expres to inhibit SARS coronavirus in vitro. In cell culture, it also blocked viral replication within times. 22 Conversely, zinc deficiency has been shown to impair immune function. 23 As was contained in a 2013 article on zinc shortfall: 24
“Zinc is a second messenger of immune cells, and intracellular free zinc in these cells participate in signaling occurrences. Zinc … is very effective in diminish the incidence of infection in the elderly. Zinc is not simply modulates cell-mediated immunity but is also an antioxidant and anti-inflammatory agent.”
The problem is that zinc is largely insoluble and cannot readily enter through the fatty wall of your cells. Get all the way into the cell is crucial, as this is where the viral replication arises. This is where zinc ionophores such as quercetin come in.
Quercetin is also a potent antiviral in its own right, and has the added advantage of hindering the 3CL protease2 5 — an enzyme used by SARS coronaviruses to infect healthy cells. 26 According to one 2020 study, 27 the ability of quercetin to hinder SARS coronaviruses “is presumed to be directly linked to suppress the activity of SARS-CoV 3CLpro in some cases.”
To this you could also add niacin( vitamin B6) and selenium, as both play a role in the absorption and bioavailability of zinc in their own bodies. For example, a study2 8 published in 1991 demonstrated that when young women were on a vitamin B6-deficient diet, their serum zinc diminished, suggesting B6 deficiency affected zinc metabolism such that “absorbed zinc was not available for utilization.”
A more in-depth expedition and explanation of both niacin and selenium’s relationship to zinc is provided in the 2008 paper, “Zinc, Metallothioneins and Longevity: Interrelationships With Niacin and Selenium.”2 9
The MATH Protocol
If you are hospitalized with COVID-1 9, early care becomes paramount. While there’s a great deal of controversy over which treatment is best, clinical testify clearly indicates mechanical ventilation should be avoided at all costs. I discussed the reasons for this in “Ventilators May Increase Risk of Death From COVID-1 9.”
Furthermore, while hydroxychloroquine combined with zinc seems effective, I belief one of the most wonderful therapies hinted so far is the MATH+ Protocol. The protocol was developed by the Front Line COVID-1 9 Critical Care Working Group, 30 which includes Dr. Paul Marik, chief of the Division of Pulmonary& Critical Care Medicine at Eastern Virginia Medical School Norfolk, and boasts a near-1 00% effectiveness rate.
The MATH+ Protocol is designed to treat the second phase of COVID-1 9 infection — the stage when the hyperinflammatory immune response gives in. For best makes, it is imperative to administered early enough, though. The MATH+ protocol3 1 calls for the use of the following three medications, all of which need to be started within six hours of hospital admission:
Intravenous methylprednisolone, to suppress the immune structure and prevent organ damage from cytokine hurricanes — For mild hypoxia, 40 milligrams( mg) daily until off oxygen; moderate to severe illness, 80 mg bolus followed by 20 mg per day for seven days. On Day 8, should be changed to oral prednisone and taper down over the next six periods.
Intravenous ascorbic acid( vitamin C ), to control inflaming and prevent the development of leaky blood vessels in the lungs — 3 grams/ 100 ml every six hours for up to seven days.
Subcutaneous heparin( enoxaparin ), to thin the blood and avoid blood clots — For mild to moderate illness, 40 mg to 60 mg daily until discharged.
Optional adds-on include thiamine, zinc and vitamin D. In addition to these medications, the protocol calls for high-flow nasal oxygen to avoid mechanical ventilation that can damage the lungs.
Together, this approach address the three core pathological processes seen in COVID-1 9, namely hyperinflammation, hypercoagulability of the blood, and hypoxia( shortness of breath due to low-toned oxygenation ).
COVID-19 Doesn’t Have to Remain a Crisis
Health experts are telling we’re likely to see a second wave of COVID-1 9 this autumn. I belief the strategies reviewed in this article can go now a long way toward minimise fatalities.
The first thing I recommend everyone do is to optimize your vitamin D this summer. Again, the optimal blood grade for health and disease prevention is between 60 ng/ mL and 80 ng/ mL.( In Europe, the measurements you’re looking for are 150 to 200 nmol/ L and 100 nmol/ L respectively .)
However, simply get above 30 ng/ mL( 75 nmol/ L) may dramatically reduce the health risks of serious infection and death, and doing so is both easy and inexpensive. As stated by Downing, we could fix the COVID-1 9 pandemic in as little as 30 days simply by making use of sure everyone is taking vitamin D in sufficiently large doses.
More detailed information about how vitamin D works and why it’s so important against COVID-1 9 can be found in my Vitamin D Report. Download and share! You can also find a summing-up of the key steps it is required to to be undertaken to optimize your tier in this previous vitamin D section. Here is the link to my comprehensive science report.
I want to thank those of you who read the above report and constructive feedback. I want you to know that I did speak those suggestions. I has so far been strategy on writing a short summary, but the responses were nearly universal in its pursuit of that.
So, when you click the button below, you will get the condensed report that you can send to your friends and family and get them on board with the Vitamin D Campaign, which not only can save many lives, but can help prevent the country from been closed down again and worsening our already shattered economy.
Taking quercetin and zinc is another preventive strategy worth noting, as is the advice to implement cyclical nutritional ketosis to make sure you’re metabolically flexible and not insulin resistant. Again, you can do this by following three powerful strategies 😛 TAGEND
Time-restricted eating window of six to eight hours
Eliminating all industrially processed vegetable oils
Limiting carbs to 50 grams per day until metabolically flexible and then increasing to 150 grams of healthy carbs twice a few weeks
More acutely, ketone esters is available through rapid succour of COVID-1 9-related symptoms such as shortness of breath, and the MATH+ Protocol, administered within six hours of hospitalization, could be a life saver.
While the Front Line COVID-1 9 Critical Care Working Group has been struggling to get the word out to doctors and infirmaries, you could( at bare minimum) request your doctor contact them and urge them to implement the protocol should you or someone you love get ill and need hospitalization.
Read more: articles.mercola.com